Work

Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

Year: 1988

Type: article

Abstract: Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci113671

Authors: J N Wilcox, K M Smith, L T Williams, S M Schwartz, D Gordon

Institutions: Genentech, Howard Hughes Medical Institute, University of California, San Francisco, University of Washington

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Washington, National Institutes of Health, National Heart, Lung, and Blood Institute