Work

The prognostic value of BRCA1 promoter methylation in early stage triple negative breast cancer

Year: 2014

Type: article

Study design: Observational Study

Abstract: INTRODUCTION: PM in TNBC patients receiving standard chemotherapy. METHODS: Subjects with stage I-III TNBC treated with chemotherapy were identified and their formalin-fixed paraffin-embedded (FFPE) tumor specimens retrieved. Genomic DNA was isolated and subjected to methylation-specific PCR (MSPCR). RESULTS: PM was associated with significantly worse RFS and OS. CONCLUSIONS: PM is common in TNBC and has the potential to identify a significant fraction of TNBC patients who have suboptimal outcomes with standard chemotherapy.

Source: journal of cancer therapeutics and research

DOI: 10.7243/2049-7962-3-2

Authors: Priyanka Sharma, Shane R Stecklein, Bruce F Kimler, Geetika Sethi, Brian K Petroff, Teresa A Phillips, Ossama W Tawfik, Andrew K Godwin, Roy A Jensen

Institutions: University of Kansas Medical Center, The University of Kansas Cancer Center, Drexel University

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute, National Center for Research Resources, National Center for Advancing Translational Sciences

Awards: Heartland Institute for Clinical and Translational Research, G700021213, G865751187, G9000199158, G9000270437, The University of Kansas Cancer Center

OpenAlex ID: W2053874726

FWCI: 2.041

Cites: 55

Cited by: 58

Related to: 10