Double-Unit Cord Blood Transplantation (DCBT) for Acute Leukemia: High Disease-Free Survival in Adults and Children with Comparable Survival in European and Minority Patients
Year: 2012
Type: article
Abstract: As DCBT may improve engraftment and protect against relapse, we have adopted DCBT for children and adults with high-risk acute leukemia, myelodysplasia (MDS), and myeloproliferative diseases (MPD). We analyzed DFS in 75 DCBT recipients with acute leukemia in morphologic remission or aplasia (n = 69), and MDS/MPD with ≤ 5% blasts (n = 6) transplanted 10/2005-4/2011. Children (n = 23, 43% AML, 52% ALL, and 4% MDS/MPD) were a median of 9 years (range 0.9-15) and 37 kg (range 7-72), 30% were European, and 26% were CMV sero-positive.
Authors: J.N. Barker, D.M. Ponce, A.M.R. Gonzales, M.N. Lubin, H. Castro-Malaspina, S.A. Giralt, J.D. Goldberg, A.A. Jakubowski, G. Koehne, E.B. Papadopoulos, M.-A. Perales, C.S. Sauter, M.R.M. van den Brink, J.W. Young, F. Boulad, R. Kobos, R.J. O'Reilly, S.E. Prockop, T.N. Small, C.E. Stevens, N.A. Kernan, A. Scaradavou
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2053961918