Work

Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria‐specific variant surface antigens

Year: 2009

Type: article

Abstract: Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.

Source: Parasite Immunology

DOI: 10.1111/j.1365-3024.2009.01097.x

Authors: J. SOERLI, L. BARFOD, T. LAVSTSEN, N. L. BERNASCONI, A. LANZAVECCHIA, L. HVIID

Institutions: University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, Institute for Research in Biomedicine

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2053982938

FWCI: 1.681

Cites: 22

Cited by: 19

Related to: 10