Work

On the dual contrast enhancement mechanism in frequency‐selective inversion‐recovery magnetic resonance angiography (IRON‐MRA)

Year: 2009

Type: article

Abstract: The susceptibility of blood changes after administration of a paramagnetic contrast agent that shortens T(1). Concomitantly, the resonance frequency of the blood vessels shifts in a geometry-dependent way. This frequency change may be exploited for incremental contrast generation by applying a frequency-selective saturation prepulse prior to the imaging sequence. The dual origin of vascular enhancement depending first on off-resonance and second on T(1) lowering was investigated in vitro, together with the geometry dependence of the signal at 3T. First results obtained in an in vivo rabbit model are presented.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.22027

Authors: Evert‐jan Vonken, Grigorios Korosoglou, Jing Yu, Michael Schär, Ralph Weissleder, Matthias Stuber