Work

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells

Year: 2010

Type: article

Abstract: Carbohydrate responsive element-binding protein (ChREBP) is a transcription factor whose expression and activity are increased in pancreatic β-cells maintained at elevated glucose concentrations. We show here that ChREBP inactivation in clonal pancreatic MIN6 β-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations. Conversely, adenovirus-mediated over-expression of ChREBP in mouse pancreatic islets results in decreases in Pdx-1, MafA, Ins1, Ins2 and GcK mRNA levels. These data suggest that strategies to reduce ChREBP activity might protect against β-cell dysfunction in type 2 diabetes.

Source: Biochemical and Biophysical Research Communications

DOI: 10.1016/j.bbrc.2010.10.010

Authors: Gabriela da Silva Xavier, Gao Sun, Qingwen Qian, Guy A. Rutter, Isabelle Leclerc

Institution: Imperial College London

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,110