Work

SPECIAL REPORT: Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro‐derivative, nitroflurbiprofen

Year: 1995

Type: article

Abstract: Nitroflurbiprofen (NFP) causes significantly less gastric lesions than flurbiprofen (FP), probably because of its capacity to release nitric oxide (NO) in the stomach. Lipopolysaccharide (LPS), which induces the expression of an inducible type of NO synthase (iNOS) in rat stomach, also reduces gastric mucosal damage elicited by FP. Furthermore, both FP and NFP decrease significantly the amount of mRNA encoding iNOS induced by LPS in the stomach. The inhibitory effect of NFP seems to be due at least in part to its ability to release NO.

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.1995.tb16650.x

Authors: S. Mariotto, M. Menegazzi, A. Carcereri de Prati, L. Cuzzolin, A. Adami, H. Suzuki, G. Benoni

Institution: University of Verona

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2054292477

FWCI: 2.087

Cites: 7

Cited by: 25

Related to: 10