Work

Developmental changes in phospholipase D activity and mRNA levels in rat brain

Year: 1998

Type: article

Abstract: Phospholipase D (PLD) activity and PLD1 mRNA levels were determined in rat brain at ages ranging from embryonic day (E) 19 to postnatal day (P) 49. Basal, oleate-, and phosphatidylinositol-4, 5-bisphosphate-stimulated PLD activity increased between E19 and P24 by approximately 3-fold and remained unaltered thereafter. A similar developmental pattern of mRNA levels of PLD1 isoform was found by Northern blotting. The development of PLD correlates with synaptogenesis and myelination suggesting that the enzyme might have an important function in these processes.

Source: Developmental Brain Research

DOI: 10.1016/s0165-3806(98)00071-6

Authors: Di Zhao, Brygida Berse, Thomas Holler, Jennifer Marie Cermak, Jan Krzysztof Blusztajn

Institution: Boston University

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute on Aging