Work

Emergence of Glass-like Behavior in Markov State Models of Protein Folding Dynamics

Year: 2013

Type: article

Abstract: The extent to which glass-like kinetics govern dynamics in protein folding has been heavily debated. Here, we address the subject with an application of space-time perturbation theory to the dynamics of protein folding Markov state models. Borrowing techniques from the s-ensemble method, we argue that distinct active and inactive phases exist for protein folding dynamics, and that kinetics for specific systems can fall into either dynamical regime. We do not, however, observe a true glass transition in any system studied. We go on to discuss how these inactive and active phases might relate to general protein folding properties.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja4002663

Authors: Jeffrey K. Weber, Robert L. Jack, Vijay S. Pande

Institutions: Stanford University, University of Bath

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Engineering and Physical Sciences Research Council, National Institute of General Medical Sciences

Awards: How fast does time flow? Dynamical behaviour in glasses, nano-science and self-assembly, Folding@Home: Simulating Folding on the Millisecond to Second Timescale