Year: 2004
Type: article
Abstract: The NF-kappaB family of transcription factors, well-known for regulating immune and inflammatory responses, has recently been identified as a molecular link between chronic inflammation and cancer. Using distinct models of inflammation-associated cancer, three recent reports now show the importance of NF-kappa B in promoting cancer progression during inflammation (Greten et al., Cell 2004, 118:285-96; Luo et al., Cancer Cell 2004, 6:297-305, Pikarsky et al., Nature 2004, 431:461-6). Results from these studies suggest that NF-kappa B exerts its oncogenic effects in both tumor cells and in the tumor microenvironment, promoting the survival of premalignant epithelial cells while also stimulating release of pro-inflammatory mediators from activated macrophages that promote tumor growth.
Source: Cancer Biology & Therapy
Authors: Dara Ditsworth, Wei-Xing Zong
Institutions: Abramson Cancer Center, University of Pennsylvania
Language: English
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2054607608