Work

Ligand–protein interactions in nuclear receptors of hormones

Year: 2000

Type: review

Abstract: Nuclear hormone receptors are transcription factors regulated by lipophilic ligands. These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(00)01672-0

Authors: Pascal F Egea, Bruno P Klaholz, Dino Moras

Institutions: Centre National de la Recherche Scientifique, Inserm, Institut de génétique et de biologie moléculaire et cellulaire

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Bristol-Myers Squibb, Association pour la Recherche sur le Cancer, Deutscher Akademischer Austauschdienst, Centre National de la Recherche Scientifique