Work

Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies

Year: 2009

Type: article

Abstract: Schizophrenia is a severe disorder that disrupts the function of multiple brain systems, resulting in impaired social and occupational functioning. The etiology and pathogenesis of schizophrenia appear to involve the interplay of a potentially large number of genetic liabilities and adverse environmental events that disrupt brain developmental pathways. In this Review, we discuss a strategy for determining how particular common and core clinical features of the illness are associated with pathophysiology in certain circuits of the cerebral cortex. The identification of molecular alterations in these circuits is providing critical insights for the rational development of new therapeutic interventions.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci37335

Authors: David A. Lewis, Robert A. Sweet

Institutions: University of Pittsburgh, Mental Illness Research, Education and Clinical Centers, VA Pittsburgh Healthcare System

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze