Work

Origin, development, and homeostasis of tissue‐resident macrophages

Year: 2014

Type: review

Abstract: Macrophages are versatile cells of the hematopoietic system that display remarkable functional diversity encompassing innate immune responses, tissue development, and tissue homeostasis. Macrophages are present in almost all tissues of the body and display distinct location-specific phenotypes and gene expression profiles. Recent studies also demonstrate distinct origins of tissue-resident macrophages. This emerging picture of ontological, functional, and phenotypic heterogeneity within tissue macrophages has altered our understanding of these cells, which play important roles in many human diseases. In this review, we discuss the different origins of tissue macrophages, the transcription factors regulating their development, and the mechanisms underlying their homeostasis at steady state.

Source: Immunological Reviews

DOI: 10.1111/imr.12215

Authors: Malay Haldar, Kenneth M. Murphy

Institutions: Washington University in St. Louis, Howard Hughes Medical Institute

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases