Tracking of Multimodal Therapeutic Nanocomplexes Targeting Breast Cancer in Vivo
Year: 2010
Type: article
Abstract: Nanoparticle-based therapeutics with local delivery and external electromagnetic field modulation holds extraordinary promise for soft-tissue cancers such as breast cancer; however, knowledge of the distribution and fate of nanoparticles in vivo is crucial for clinical translation. Here we demonstrate that multiple diagnostic capabilities can be introduced in photothermal therapeutic nanocomplexes by simultaneously enhancing both near-infrared fluorescence and magnetic resonance imaging (MRI). We track nanocomplexes in vivo, examining the influence of HER2 antibody targeting on nanocomplex distribution over 72 h. This approach provides valuable, detailed information regarding the distribution and fate of complex nanoparticles designed for specific diagnostic and therapeutic functions.
Source: Nano Letters
DOI: 10.1021/nl102889y
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G1117636149, RTE/FDPM for optical imaging of cancer in small animal models, G4030003157, Molecularly guided multimodal theranostics for breast cancer, Translational Research in Breast Cancer, Diabetes Endocrinology Research Center, Baylor College of Medicine Cancer Center - Cancer Center Support Grant
OpenAlex ID: W2054849397