Work

The role of single nucleotide polymorphisms in breast cancer metastasis

Year: 2008

Type: article

Abstract: Our understanding of many aspects of cancer biology has been advanced through the use of modern genetics. These studies have already shown that germ line polymorphisms play a significant role in disease initiation and response to therapy. However, what is less well studied is the role of germ line polymorphisms in cancer progression. Studies in rodents indicate that differential susceptibility to cancer metastasis can be heritable; thus, the search for the genes that control cancer metastasis is underway. Although some provocative studies suggest potential candidates for metastasis regulating genes, the conclusive identification of a specific inherited genetic variant that alters metastatic potential awaits further studies.

Source: Breast Cancer Research

DOI: 10.1186/bcr1842

Authors: James M Rae, Todd C Skaar, Susan G Hilsenbeck, Steffi Oesterreich

Institutions: University of Michigan, Michigan Medicine, Indiana University Indianapolis, Indiana University School of Medicine, Baylor College of Medicine

Language: English

Topic: Mechanisms of cancer metastasis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190