Work

Regenerative Electronic Biosensors Using Supramolecular Approaches

Year: 2013

Type: article

Abstract: A supramolecular interface for Si nanowire FETs has been developed with the aim of creating regenerative electronic biosensors. The key to the approach is Si-NWs functionalized with β-cyclodextrin (β-CD), to which receptor moieties can be attached with an orthogonal supramolecular linker. Here we demonstrate full recycling using the strongest biomolecular system known, streptavidin (SAv)-biotin. The bound SAv and the linkers can be selectively removed from the surface through competitive desorption with concentrated β-CD, regenerating the sensor for repeated use. An added advantage of β-CD is the possibility of stereoselective sensors, and we demonstrate here the ability to quantify the enantiomeric composition of chiral targets.

Source: ACS Nano

DOI: 10.1021/nn306034f

Authors: Xuexin Duan, Nitin K. Rajan, David A. Routenberg, Jurriaan Huskens, Mark A. Reed

Institutions: Yale University, University of Twente

Language: English

Topic: Nanowire Synthesis and Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering