Work

A New Sodium Channel α-Subunit Gene (Scn9a) from Schwann Cells Maps to theScn1a, Scn2a, Scn3aCluster of Mouse Chromosome 2

Year: 1996

Type: article

Abstract: We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an alpha-subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel alpha-subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2.

Source: Genomics

DOI: 10.1006/geno.1996.0447

Authors: Marie-Claire Beckers, Eric Ernst, Scott Belcher, James Howe, Robert Levenson, Philippe Gros

Institutions: McGill University, Yale University, Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,980

OpenAlex ID: W2055406919

FWCI: 0.631

Cites:

Cited by: 18

Related to: 10