Antioxidant and Anti-cholinesterase Activity of Globularia meridionalis Extracts and Isolated Constituents
Year: 2012
Type: article
Abstract: The antioxidant and anti-cholinesterase properties of Globularia meridionalis (Podp.) O. Schwarz (Globulariaceae) were investigated. G. meridionalis aerial parts and roots were extracted with methanol, and the total extract successively partitioned with n-hexane. The methanol fraction of the roots showed the highest antioxidant activity with IC50 values of 8.0 and 2.1 microg/mL in the DPPH and beta-carotene bleaching tests, respectively. From this fraction, three flavonoids, namely pectolinarigenin 7-O-beta-glucoside, apigenin 7-O-beta-glucoside and luteolin, and two phenylethanoids, namely acteoside and isoacteoside, were isolated. Potential anti-cholinesterase effects were assessed through the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibition assay. The n-hexane fraction of the roots exhibited the highest activity against both AChE and BChE with IC50 values of 65.5 and 70.4 microg/mL, respectively.
Source: Natural Product Communications
Authors: Rosa Tundis, Marco Bonesi, Federica Menichini, Monica R. Loizzo, Filomena Conforti, Giancarlo Statti, Filippo M. Pirisi, Francesco Menichini
Institutions: University of Calabria, University of Cagliari
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
Funder: Università di Pisa
OpenAlex ID: W205569198