Work

Regulation of store-operated calcium entry during cell division

Year: 2012

Type: article

Abstract: Store-operate Ca2+ channels gate Ca2+ entry into the cytoplasm in response to the depletion of Ca2+ from endoplasmic reticulum Ca2+ stores. The major molecular components of store-operated Ca2+ entry are STIM (stromal-interacting molecule) 1 (and in some instances STIM2) that serves as the endoplasmic reticulum Ca2+ sensor, and Orai (Orai1, Orai2 and Orai3) which function as pore-forming subunits of the store-operated channel. It has been known for some time that store-operated Ca2+ entry is shut down during cell division. Recent work has revealed complex mechanisms regulating the functions and locations of both STIM1 and Orai1 in dividing cells.

Source: Biochemical Society Transactions

DOI: 10.1042/bst20110612

Authors: Jeremy T. Smyth, James W. Putney

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Environmental Health Sciences

Award: Capacitative Calcium Entry