Work

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

Year: 2011

Type: article

Source: Nature Structural & Molecular Biology

DOI: 10.1038/nsmb.2095

Authors: Angeline M Lyon, Valerie M Tesmer, Vishan D Dhamsania, David M Thal, Joanne Gutierrez, Shoaib Chowdhury, Krishna C Suddala, John K Northup, John J G Tesmer

Institutions: University of Michigan, National Institutes of Health, National Institute on Deafness and Other Communication Disorders

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: University of Texas Southwestern Medical Center, National Institutes of Health, Medical Center, University of Rochester, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1200148395, G2055771504, Michigan Diabetes Research and Training Center, Structural and Functional Studies of Galphaq and Its Signaling Complexes, G4675322906, Structure, function, and inhibition of G protein-coupled receptor kinases, Michigan Diabetes Research Center (MDRC)

OpenAlex ID: W2055828189

FWCI: 3.534

Cites: 53

Cited by: 82

Related to: 10