Work

Strong evidence for protein epistasis, weak evidence against it

Year: 2014

Type: letter

Abstract: A recent paper by Ashenberg et al. (1) reports protein stability measurements and computational simulations that they claim contradict the results of our previous paper describing a “Stokes shift” in protein evolution (2). They make strong assertions that coevolutionary interactions among amino acids due to effects on stability do not significantly modify amino acid preferences or evolutionary patterns and thus are unimportant for phylogenetics. However, on review, we find their experimental results are highly compatible with epistasis and Stokes shift theory. The apparent contradiction arises from their making sparse measurements on closely related strains of influenza, an inappropriate model system, and from ignoring most …

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1401112111

Authors: David D. Pollock, Richard A. Goldstein

Institutions: University of Colorado Anschutz, University of Colorado Denver, University College London

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Medical Research Council, National Institute of General Medical Sciences

Awards: Modelling the Evolution of Molecular Components, Systems & Behaviours in respect of the transition of Dr Richard Goldstein from MRC NIMR to UCL, Genome-wide mutation models to decipher function

OpenAlex ID: W2055968189

Cites: 4

Cited by: 30

Related to: 10