Work

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Year: 2008

Type: article

Study design: Observational Study

Abstract: IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

Source: AIDS

DOI: 10.1097/qad.0b013e3282ff884e

Authors: Lishomwa C Ndhlovu, Joan M Chapman, Aashish R Jha, Jennifer E Snyder-Cappione, Moraima Pagán, Fabio E Leal, Brigid S Boland, Philip J Norris, Michael G Rosenberg, Douglas F Nixon

Institutions: San Francisco General Hospital, University of California, San Francisco, Blood Systems Research Institute, Albert Einstein College of Medicine, Yeshiva University, Jacobi Medical Center

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: (CHAVI) Center for HIV/AIDS Vaccine Immunology, G200995756, Cell Mediated Immunity in HIV Infected Children, G4509817347, Cell Mediated Immunity in HIV Infected Children, T Regulatory Cells in HIV Infection, G7545256403, (CHAVI) Center for HIV/AIDS Vaccine Immunology, UCSF-Bay Area Center for AIDS Research

OpenAlex ID: W2056029392

FWCI: 3.144

Cites: 15

Cited by: 75

Related to: 10