Year: 2012
Type: review
Abstract: Multiple myeloma is a monoclonal tumor of plasma cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormalities, including universal dysregulation of the cyclin D/retinoblastoma (cyclin D/RB) pathway. A complex interaction with the BM microenvironment, characterized by activation of osteoclasts and suppression of osteoblasts, leads to lytic bone disease. Intratumor genetic heterogeneity, which occurs in addition to intertumor heterogeneity, contributes to the rapid emergence of drug resistance in high-risk disease. Despite recent therapeutic advances, which have doubled the median survival time, myeloma continues to be a mostly incurable disease. Here we review the current understanding of myeloma pathogenesis and insight into new therapeutic strategies provided by animal models and genetic screens.
DOI: 10.1172/jci61188
Authors: W. Michael Kuehl, P. Leif Bergsagel
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Mouse Model of Age-Associated Monoclonal Gammopathy, SPORE in Multiple Myeloma, G5327755220, G6777264179, G7028491909, Molecular Pathogenesis of Multiple Myeloma, Mouse Models of Age-Associated Monoclonal Gammopathy, Comparative Pharmaco-oncogenomics of Myeloma Drug Resistance, G8786338181, G9000066536, G9000159975, G918026202
OpenAlex ID: W2056172893