Year: 2013
Type: article
Abstract: Hyperzincaemia and hypercalprotectinaemia (Hz/Hc), a rare condition within the spectrum of autoinflammatory diseases, is associated with hepatosplenomegaly, arthritis, anemia, cutaneous inflammation, and failure to thrive. So far, no genetic cause has been identified. While the clinical appearance is heterogeneous, all affected individuals present with extremely elevated MRP8/MRP14 (calprotectin) serum concentrations (0.9-12.0 g/l (normal range < 0.001 g/l)).
Source: Pediatric Rheumatology
Authors: D Holzinger, P Lohse, S Faßl, J Austermann, T Vogl, W de Jager, S Holland, M Gattorno, C Rodriguez-Gallego, J Arostegui, S Fessatou, B Isidor, K Ito, H-J Epple, J Bernstein, M Jeng, G Lionetti, P Ong, C Hinze, B Sampson, C Sunderkoetter, D Foell, J Chae, A Ombrello, J Brady, I Aksentijevich, J Roth
Institutions: University Hospital Münster, Ludwig-Maximilians-Universität München, University Medical Center Utrecht, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Istituto Giannina Gaslini, Hospital Universitario de Gran Canaria Doctor Negrín, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, National and Kapodistrian University of Athens, Centre Hospitalier Universitaire de Nantes, Nagoya City University, Charité – Universitätsmedizin Berlin, Stanford Medicine, Children's Hospital Los Angeles, German Center for Pediatric and Adolescent Rheumatology, Charing Cross Hospital, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,090
OpenAlex ID: W2056202855