Transforming Growth Factor-β
Year: 2005
Type: book-chapter
Abstract: Transforming growth factor (TGF)-beta is a prototypic multifunctional cytokine whose broad modulatory mechanisms affect numerous biological functions both at the cell and organism levels. These include, but are not limited to, control of immune functions, embryogenesis, carcinogenesis, tissue responses to injury, cell proliferation, extracellular matrix (ECM) synthesis and degradation, and cell migration. The identification of Smad proteins, TGF-beta receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, has increased our understanding of the molecular mechanisms underlying TGF-beta action. This introductory chapter will outline the current knowledge on how specific signals initiated by the TGF-beta receptors are brought to the nucleus to regulate gene expression, with a specific emphasis on how such signaling relates to connective tissue remodeling, repair, and fibrosis.
Source: Humana Press eBooks
Author: Alain Mauviel
Institutions: Inserm, Hôpital Saint-Louis
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W205625670