Work

Deamidation of human proteins

Year: 2001

Type: article

Abstract: Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.221463198

Authors: N. E. Robinson, A. B. Robinson

Institution: California Institute of Technology

Language: English

Topic: Protein purification and stability

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2056300299

FWCI: 1.731

Cites: 34

Cited by: 295

Related to: 9