Work

Rapid in vivo acquisition of effector Tc1 phenotype prior to myeloid engraftment predicts opportunistic infections in unrelated cord blood transplant recipients

Year: 2006

Type: article

Abstract: The major cause of morbidity and mortality after unrelated cord blood transplantation (UCBT) is opportunistic infections (OI), most occurring in the first 100 days due to viral agents. Despite >5 × 106/kg of T cells in UCB grafts they are naive, lack expression of Th1/Tc1 cytokines, granzymes A, B, and perforin, prerequisites for controlling viral pathogens. We postulated that following transplant the infused T cells will undergo phenotypic alterations induced by the lymphopenic environment and emerging de novo or latent viruses.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.259

Authors: P. Szabolcs, Y.A. Lee, M. Reese, N. Chao, J. Kurtzberg

Institutions: Duke Medical Center, Duke University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650