A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells

Year: 2013

Type: article

Abstract: We compared different techniques for measuring gut HIV reservoirs and assessed for HIV in non-CD4 T cells. HIV DNA levels were similar when measured from rectal biopsies and isolated rectal cells, while HIV RNA tended to be higher in rectal cells. HIV DNA levels in total rectal cells were greater than those predicted from levels in sorted CD4 T cells, suggesting a reservoir in non-CD4 T cells, and HIV DNA was detected in sorted myeloid cells (7/7 subjects).

Source: AIDS

DOI: 10.1097/qad.0000000000000166

Authors: Steven A. Yukl, Elizabeth Sinclair, Ma Somsouk, Peter W. Hunt, Lorrie Epling, Maudi Killian, Valerie Girling, Peilin Li, Diane V. Havlir, Steven G. Deeks, Joseph K. Wong, Hiroyu Hatano

Institutions: San Francisco VA Medical Center, University of California, San Francisco

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, Delaney AIDS Research Enterprise, National Institutes of Health, Center for AIDS Research, University of Washington, University of California, San Francisco, National Cancer Institute, National Institute of Allergy and Infectious Diseases

OpenAlex ID: W2056849508