Work

An Alternative to the Sandmeyer Approach to Aryl Iodides

Year: 2015

Type: article

Abstract: Iodoarenes are important synthons for a wide range of organic transformations. Here we report a general strategy to prepare singly iodinated electron-rich aromatic compounds through the intermediacy of diaryliodonium salts. This process, which incorporates a phase separation that greatly simplifies product purification, is an attractive replacement for the Sandmeyer approach to iodoarenes that are otherwise difficult to access.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.201500151

Authors: Bao Hu, William H. Miller, Kiel D. Neumann, Ethan J. Linstad, Stephen G. DiMagno

Institutions: University of Nebraska–Lincoln, Zhejiang University of Technology

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Award: Synthesis of Radiofluorinated PET Imaging Agents