EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management
Year: 2015
Type: review
Abstract: Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, affecting >90% of the adult population. EBV targets B-lymphocytes and achieves latent infection in a circular episomal form. Different latency patterns are recognized based on latent gene expression pattern. Latent membrane protein-1 (LMP-1) mimics CD40 and, when self-aggregated, provides a proliferation signal via activating the nuclear factor-kappa B, Janus kinase/signal transducer and activator of transcription, phosphoinositide 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase pathways to promote cellular proliferation. LMP-1 also induces BCL-2 to escape from apoptosis and gives a signal for cell cycle progression by enhancing cyclin-dependent kinase 2 and phosphorylation of retinoblastoma (Rb) protein and by inhibiting p16 and p27. LMP-2A blocks the surface immunoglobulin-mediated lytic cycle reactivation. It also activates the Ras/PI3K/Akt pathway and induces Bcl-xL expression to promote B-cell survival. Recent studies have shown that ebv-microRNAs can provide extra signals for cellular proliferation, cell cycle progression and anti-apoptosis. EBV is well known for association with various types of B-lymphocyte, T-lymphocyte, epithelial cell and mesenchymal cell neoplasms. B-cell lymphoproliferative disorders encompass a broad spectrum of diseases, from benign to malignant. Here we review our current understanding of EBV-induced lymphomagenesis and focus on biology, diagnosis and management of EBV-associated B-cell lymphoproliferative disorders.
DOI: 10.1038/emm.2014.82
Authors: Chi Young Ok, Ling Li, Ken H Young
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,490
Awards: G1468253849, G1901027039, Deep Sequencing of Small Regulatory RNAs in Diffuse Large B cell Lymphoma, M. D. Anderson Cancer Center SPORE in Multiple Myeloma, G5205017604, G6736661663, G7891028497, Convergence of MicroRNAs and p53 Signaling in Multiple Myeloma: Environmental Co, G8122636988, G8492985506, UT M.D. Anderson Cancer Center Lymphoma SPORE, G9000061078, G9000284475, Cancer Center Support Grant
OpenAlex ID: W2056999501