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Different Neural Substrates Mediate Cocaine Seeking after Abstinence versus Extinction Training: A Critical Role for the Dorsolateral Caudate–Putamen

Year: 2006

Type: article

Abstract: Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse. However, relapse typically occurs after abstinence rather than explicit extinction training. We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence. This suggests that there is limited overlap in the substrates of cocaine seeking after abstinence versus extinction, and that habit learning exerts greater control over drug seeking than regions implicated in stimulus-reward associations.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.5146-05.2006

Authors: Rita A. Fuchs, R. Kyle Branham, Ronald E. See

Institution: Medical University of South Carolina

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute on Drug Abuse