Work

Nuclear survivin as a biomarker for non-small-cell lung cancer

Year: 2004

Type: article

Study design: Observational Study

Abstract: Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.

Source: British Journal of Cancer

DOI: 10.1038/sj.bjc.6602027

Authors: B Lu, A Gonzalez, P P Massion, Y Shyr, B Shaktour, D P Carbone, D E Hallahan

Institutions: Vanderbilt University, Vanderbilt-Ingram Cancer Center

Language: English

Topic: Lung Cancer Research Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190

Funders: Vanderbilt University, Vanderbilt-Ingram Cancer Center, National Cancer Institute

Awards: X-Ray Guided Drug Delivery Systems, SPORE in Lung Cancer, FLK1 Signaling Protects Tumor Vasculature from Radiation

OpenAlex ID: W2057058531

FWCI: 2.732

Cites: 19

Cited by: 71

Related to: 10