Work

Normal and transforming functions of RUNX1: A perspective

Year: 2005

Type: review

Abstract: Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.20538

Authors: Fady M. Mikhail, Kislay K. Sinha, Yogen Saunthararajah, Giuseppina Nucifora

Institutions: University of Alabama at Birmingham, Alexandria University, University of Illinois Chicago

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute