Work

The Angiotensin II AT2 Receptor Is an AT1Receptor Antagonist

Year: 2001

Type: article

Abstract: The vasopressor angiotensin II activates AT(1) and AT(2) receptors. Most of the known in vivo effects of angiotensin II are mediated by AT(1) receptors while the biological functions of AT(2) receptors are less clear. We report here that the AT(2) receptor binds directly to the AT(1) receptor and thereby antagonizes the function of the AT(1) receptor. The AT(1)-specific antagonism of the AT(2) receptor was independent of AT(2) receptor activation and signaling, and it was effective on different cells and on human myometrial biopsies with AT(1)/AT(2) receptor expression. Thus, the AT(2) receptor is the first identified example of a G-protein-coupled receptor which acts as a receptor-specific antagonist.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.m105253200

Authors: Said AbdAlla, Heinz Lother, Ahmed M. Abdel-tawab, Ursula Quitterer

Institutions: Ain Shams University Hospital, Leibniz Institute of Virology (LIV), University of Würzburg

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430