Work

Generation and characterization of xenospecific human suppressor T cells

Year: 1999

Type: article

Abstract: DESPITE continuous improvements in pharmacologic \nstrategies aimed to prevent transplant rejection, the \nunwanted effect of nonspecific immunosuppression and the \nirreversible nature of vascular rejection remain critical \nproblems. These problems are likely to be resolved only by \nthe development of new means for induction of donorspecific \ntolerance in adult recipients. \nProgress in this direction has been made recently through \nthe discovery of immunoregulatory T-suppressor cells that \ninhibit the activation and proliferation of allospecific human \nT-helper lymphocytes.1,2 \nBecause xenotransplantation of pig organs into human \nrecipients is one of the most desirable solutions to the organ \nshortage problem we have explored the possibility of generating \nhuman suppressor T-cell lines (Ts), which can \ninhibit T-helper-cell (Th) reactivity against pig MHC class \nII antigens.

Source: Transplantation Proceedings

DOI: 10.1016/s0041-1345(98)01861-2

Authors: N Suciu-Foca, R Ciubotariu, A.I Colovai, Z Liu, P Berloco, R Cortesini

Institutions: Columbia University, Università Campus Bio-Medico, Sapienza University of Rome

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,390