Work

C-FLIP Expression Determines Low Sensitivity Of Type 17 T Helper Cells To Activation-Induced Cell Death

Year: 2009

Type: article

Abstract: T cell apoptosis induced by repeated TCR stimulation, known as activation-induced cell death (AICD), plays an important role in T cell tolerance. Pro-inflammatory, IL-17-producing CD4+ T cells (Th17 cells) have been recently identified as a unique T helper subset. Preliminary work from our lab indicated that Th17 cells participate in the pathogenesis of acute graft-versus-host disease (GVHD). In this study, we compared the susceptibility of polarized Th1 and Th17 effectors to AICD in vitro and in vivo.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.12.367

Authors: Y. Yu, C. Iclozan, C. Anasetti, C. Dong, X.-Z. Yu

Institutions: Moffitt Cancer Center, The University of Texas MD Anderson Cancer Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650