Work

Clinical toxicologic and pharmacologic studies of gallium nitrate

Year: 1979

Type: article

Abstract: Gallium nitrate, administered intravenously to patients with advanced cancer, produced renal functional abnormalities consistently at a dose of 750 mg/m2. The toxicity at that dose could be modified by fluid loading and osmotic diuresis. Pharmacokinetic studies revealed a biphasic half-life, (T 1/2 alpha = 87 minutes and T 1/2 beta = 24.5 hours). Osmotic diuresis reduced the urinary concentration of gallium but did not affect serum levels or clearance.

Source: Cancer

DOI: 10.1002/1097-0142(197911)44:5<1722::aid-cncr2820440528>3.0.co;2-c

Authors: Irwin H. Krakoff, Robert A. Newman, Ronald S. Goldberg

Institution: University of Vermont

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Association for Cancer Research, National Cancer Institute