Work

Modulation of aldehyde dehydrogenase activitiy and retinoid signaling induces hematopoietic stem cell self renewal

Year: 2006

Type: article

Abstract: Aldehyde dehydrogenases are cytosolic enzymes that convert aldehydes into carboxylic acids. Human aldehyde dehydrogenase 1 (ALDH1) is highly expressed in the liver and in hematopoietic stem cells (HSCs). Although ALDH1 is a selectable marker of HSCs, its HSC-specific function is unknown. We hypothesized that ALDH might play a critical role in HSC fate determinations since it is required for the production of retinoic acids, which are broadly implicated in tissue differentiation, tissue patterning, and embryonic development in vertebrates.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.330

Authors: G. Muramoto, R. Safii, N.J. Chao, M. Colvin, D. McDonnell, J.P. Chute

Institution: Duke University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650