Cyclosporine Area Under the Curve in Children Undergoing Haematopoietic Stem Cell Transplantation: Limited Sampling Strategy at Steady-State
Year: 2012
Type: article
Abstract: Haematopoietic stem cell transplantation (HSCT) outcomes may be optimized by cyclosporine dose adjustment according to systemic exposure (measured by area under the curve (AUC)) rather than trough concentration. We have previously developed and validated a limited sampling strategy (LSS) for estimating cyclosporine AUC after the initial IV dose in children undergoing HSCT. In this study we aim to develop a LSS to estimate AUC at steady-state.
Institutions: Hospital for Sick Children, London Health Sciences Centre
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2058196828