Work

Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex

Year: 1999

Type: article

Abstract: We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-beta expression in CD25+44- thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-beta expression can be accounted for by pre-TCR-dependent signal mediation, putting into question the function of a putative pro-TCR.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.190.1.141

Authors: Iannis Aifantis, Jacqueline Feinberg, Hans Jörg Fehling, James P. Di Santo, Harald von Boehmer

Institutions: Hôpital Necker-Enfants Malades, Inserm, Institut Necker Enfants Malades

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2058227109