Year: 2010
Type: article
Abstract: Replication forks and transcription complexes often collide, which can result in mutagenesis and chromosomal rearrangements. Recent studies of E. coli demonstrate a role for transcription factors in reducing conflicts between replication and transcription. These findings suggest that transcription regulators preserve genome integrity by preventing replication fork arrest.
Source: Transcription
Authors: Richard T. Pomerantz, Mike O’Donnell
Institutions: Howard Hughes Medical Institute, Rockefeller University
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funder: Ministry of Food and Drug Safety
OpenAlex ID: W2058239620