Work

Systemic lithium administration alters rat cerebral cortex phospholipids

Year: 1987

Type: article

Abstract: Systemic lithium administration is known to alter the metabolism of myo-inositol and choline, both of which are precursors for phospholipid synthesis. We report that systemic administration also induces a number of changes in the relative levels of rat cerebral cortex phospholipids, including phosphatidylinositol, phosphatidylcholine, sphingomyelin, and phosphatidylethanolamine. As phospholipids play an integral role in the maintenance of biological membranes, these changes are functionally quite significant and may have implications for a better understanding of lithium's therapeutic actions.

Source: Biological Psychiatry

DOI: 10.1016/0006-3223(87)90181-8

Authors: Natalie E. Joseph, Perry F. Renshaw, John S. Leigh

Institution: University of Pennsylvania

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,489