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Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis

Year: 2011

Type: article

Abstract: Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population.To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS).A total 3,793 samples (476 cases: wrist ＋ knee and 3317 controls) from a community-based epidemiological study were genotyped using the Affymetrix SNP 5.0.An intronic SNP (rs4789934) in the TIMP2 (tissue inhibitor of metalloproteinase-2) showed the most significance with OA (odd ratio [OR] = 2.06, 95% confidence interval [CI] = 1.52-2.81,p = 4.01 × 10 -6).Furthermore, a polymorphism (rs1352677) in the NKAIN2 (Na ＋ /K ＋ transporting ATPase interacting 2) was suggestively associated with OA (OR = 1.43,CI = 1.22-1.66,p = 7.01 × 10 -6).The present study provides new insights into the identification of genetic predisposing factors for OA.

Source: Genomics & Informatics

DOI: 10.5808/gi.2011.9.3.121