Work

Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen–Friedenreich (T) antigens and their sialylated derivatives

Year: 2012

Type: article

Abstract: Fluorinated Thomsen-Friedenreich (T) antigens were synthesized efficiently from chemically produced fluorinated monosaccharides using a highly efficient one-pot two-enzyme chemoenzymatic approach containing a galactokinase and a D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase. These fluorinated T-antigens were further sialylated to form fluorinated ST-antigens using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α-2-3-sialyltransferase.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c2ob26989a

Authors: Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Institutions: Shandong University, University of California, Davis, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Award: Oligosaccharides as antimicrobials and prebiotics