Work

Ethanol's antiseizure efficacy is reduced by stress

Year: 1992

Type: article

Abstract: The ability of ethanol to antagonize the electrical precipitation of seizures in an incremental electroconvulsive shock paradigm was examined in groups of stressed and control mice. In stressed mice, the dose-response curve for ethanol's antiseizure efficacy was down-shifted and right-shifted relative to controls. These data may have clinical implications with respect to the interaction between stress, ethanol, and proneness to seizures.

Source: Pharmacology Biochemistry and Behavior

DOI: 10.1016/0091-3057(92)90390-2

Authors: John Mastropaolo, Monica R. Novitzki, Stephen I. Deutsch

Institutions: United States Department of Veterans Affairs, Veterans Health Administration, Washington DC VA Medical Center, Georgetown University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650