Work

A Brief Review of Short Tandem Repeat Mutation

Year: 2007

Type: review

Abstract: Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.

Source: Genomics Proteomics & Bioinformatics

DOI: 10.1016/s1672-0229(07)60009-6

Authors: Hao Fan, Jia-You Chu

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming Medical University

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,850