Work

DNA Nanotubes as Combinatorial Vehicles for Cellular Delivery

Year: 2008

Type: article

Abstract: This work explores using self-assembled DNA nanostructures as carriers for drug delivery. We have recently developed an organic nanotube system that is assembled from a single component: a 52-base-long DNA single strand. In this work, functional agents (folate as a cancer cell target agent and Cy3 as a fluorescence imaging agent) are conjugated with the DNA strands; the conjugates self-assemble into micrometers-long nanotubes (NTs). The conjugated DNA-NTs can be effectively taken by cancer cells as demonstrated by fluorescence imaging and fluorescence-activated cell sorting. No obvious toxicity has been observed under current experimental conditions.

Source: Biomacromolecules

DOI: 10.1021/bm800479e

Authors: SeungHyeon Ko, Haipeng Liu, Yi Chen, Chengde Mao

Institution: Purdue University West Lafayette

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering