Work

The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups

Year: 2009

Type: article

Abstract: Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights and compares the available methods for these transformations.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.200800776

Authors: Barry M. Trost, Andrew H. Weiss

Institutions: Stanford University, Harvard University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, Foundation for the National Institutes of Health, National Institute of General Medical Sciences

Award: Novel Approaches for Antitumor and Antiviral Agents