Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes
Year: 2006
Type: article
Study design: Observational Study
Abstract: Chromosomal translocations, insertions, and deletions are common early events in non-Hodgkin lymphoma (NHL) carcinogenesis, and implicated in their formation are endogenous processes involved in antigen-receptor diversification, such as V(D)J recombination. DNA repair genes respond to the double- and single-strand breaks induced by these processes and may influence NHL etiology. We examined 34 genetic variants in 19 genes within or related to 5 DNA repair pathways among 1172 cases and 982 matched controls who participated in a population-based NHL study in Los Angeles, Seattle, Detroit, and Iowa from 1998 to 2000. Cases were more likely than controls to have the RAG1 820 R/R (odds ratio [OR] = 2.7; 95% confidence interval [CI] = 1.4 to 5.0) than Lys/Lys genotypes, with evidence of a gene dosage effect (P trend < .001), and less likely to have the LIG4 (DNA ligase IV) 9 Ile/Ile (OR = 0.5; 95% CI = 0.3 to 0.9) than T/T genotype (P trend = .03) in the nonhomologous end joining (NHEJ)/V(D)J pathway. These NHEJ/V(D)J-related gene variants represent promising candidates for further studies of NHL etiology and require replication in other studies.
Source: Blood
Institutions: University of Southern California, University of Iowa, United States Department of Health and Human Services, National Institutes of Health, Mayo Clinic, University of New Mexico, Wayne State University, University of Washington, Fred Hutch Cancer Center, The Barbara Ann Karmanos Cancer Institute, National Cancer Institute, UNM Comprehensive Cancer Center, Division of Cancer Epidemiology and Genetics
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2058849293