Work

Considerable Differences in Vaccine Immunogenicities and Efficacies Related to the Diluent Used for Aluminum Hydroxide Adjuvant

Year: 2008

Type: article

Abstract: We are developing an anticandidal vaccine using the recombinant N terminus of Als3p (rAls3p-N). We report that although more rAls3p-N was bound by aluminum hydroxide diluted in saline than by aluminum hydroxide diluted in phosphate-buffered saline (PBS), its immunogenicity and efficacy were superior in PBS. Thus, protein binding, by itself, may not predict the efficacy of some vaccines with aluminum adjuvants.

Source: Clinical and Vaccine Immunology

DOI: 10.1128/cvi.00427-07

Authors: Lin Lin, Ashraf S. Ibrahim, Valentina Avanesian, John E. Edwards, Yue Fu, Beverlie Baquir, Rebecca Taub, Brad Spellberg

Institutions: University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: American Heart Association, Bristol-Myers Squibb, National Institute of Allergy and Infectious Diseases

Awards: Candida Adherence & Penetration of Vascular Endothelium, Adrenergic Antagonism During Murine Candidiasis, G34114487, G427478992, Mechanisms of Als vaccine protection against S. aureus, Vaccine Strategies for Disseminated Candidiasis

OpenAlex ID: W2059016354

FWCI: 1.723

Cites: 20

Cited by: 24

Related to: 10